{"id":121618,"date":"2020-06-26T15:31:34","date_gmt":"2020-06-27T01:31:34","guid":{"rendered":"https:\/\/www.hawaii.edu\/news\/?p=121618"},"modified":"2021-04-21T13:29:54","modified_gmt":"2021-04-21T23:29:54","slug":"change-seq-target-gene-editing","status":"publish","type":"post","link":"https:\/\/www.hawaii.edu\/news\/2020\/06\/26\/change-seq-target-gene-editing\/","title":{"rendered":"Genome editing for children\u2019s diseases could boost agricultural production"},"content":{"rendered":"Reading time: <\/span> < 1<\/span> minute<\/span><\/span>
\"Yanghua
Yanghua He<\/figcaption><\/figure>\n

A recent study from St.<\/abbr> Jude Children\u2019s Research Hospital describes a new method for genome editing that could lead to safer, more targeted strategies for treating and potentially curing life-threatening diseases, such as some cancers and blood diseases—with less risk of unwanted mutations.<\/p>\n

CHANGE-seq<\/abbr>, or “circularization for high-throughput analysis of nuclease genome-wide effects by sequencing,” is a new method for identifying regions in the genome where a gene-editing process, such as CRISPR<\/abbr>-Cas9, is more likely to misidentify the intended target site.<\/p>\n

The research team included Yanghua He<\/strong>, who recently joined the University of Hawaiʻi<\/span> at M\u0101noa\u2019s College of Tropical Agriculture and Human Resources (CTAHR<\/abbr>) Department of Human Nutrition, Food and Animal Sciences<\/a> from St.<\/abbr> Jude, and her colleagues.<\/p>\n