{"id":123581,"date":"2020-07-28T09:03:52","date_gmt":"2020-07-28T19:03:52","guid":{"rendered":"https:\/\/www.hawaii.edu\/news\/?p=123581"},"modified":"2020-07-31T13:59:39","modified_gmt":"2020-07-31T23:59:39","slug":"uh-covid-19-in-early-trials","status":"publish","type":"post","link":"https:\/\/www.hawaii.edu\/news\/2020\/07\/28\/uh-covid-19-in-early-trials\/","title":{"rendered":"<abbr title=\"University of Hawaii\">糖心视频<\/abbr> research develops promising COVID-19 vaccine in early trials"},"content":{"rendered":"<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Reading time: <\/span> <span class=\"rt-time\"> &lt; 1<\/span> <span class=\"rt-label rt-postfix\">minute<\/span><\/span><p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2020\/03\/system-coronavirus.jpg\" alt=\"coronavirus\" width=\"676\" height=\"381\" class=\"aligncenter size-full wp-image-112230\" srcset=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2020\/03\/system-coronavirus.jpg 676w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2020\/03\/system-coronavirus-300x169.jpg 300w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2020\/03\/system-coronavirus-130x73.jpg 130w\" sizes=\"auto, (max-width: 676px) 100vw, 676px\" \/><\/p>\n<p>A <a href=\"https:\/\/www.hawaii.edu\/news\/2020\/03\/23\/jabsom-scientist-covid-vaccine\/\">vaccine candidate that shows promise in rapidly inducing immunity to the novel coronavirus<\/a> in pre-clinical trials has been developed by a University of <span aria-label=\"Hawaii\">Hawai&#699;i<\/span> at M\u0101noa researcher, in collaboration with a pharmaceutical company.<\/p>\n<p><strong>Axel Lehrer<\/strong>, an assistant professor at the <a href=\"http:\/\/jabsom.hawaii.edu\">John A. Burns School of Medicine<\/a>, is leading a team of scientists in the Department of Tropical Medicine, Medical Microbiology and Pharmacology, collaborating with New Jersey-based Soligenix, Inc. on the project.<\/p>\n<figure id=\"attachment_66454\" aria-describedby=\"caption-attachment-66454\" style=\"width: 214px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2017\/09\/manoa-jabsom-lehrer-a-214x300.jpg\" alt=\"Axel Lehrer\" width=\"214\" height=\"300\" class=\"size-medium wp-image-66454\" srcset=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2017\/09\/manoa-jabsom-lehrer-a-214x300.jpg 214w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2017\/09\/manoa-jabsom-lehrer-a.jpg 250w\" sizes=\"auto, (max-width: 214px) 100vw, 214px\" \/><figcaption id=\"caption-attachment-66454\" class=\"wp-caption-text\">Axel Lehrer<\/figcaption><\/figure>\n<p>The Lehrer Laboratory, Soligenix, and <span aria-label=\"Hawaii\">Hawai&#699;i<\/span><br \/>\n-based Hawaii Biotech, Inc., have previously demonstrated the feasibility of developing a thermostable Ebola virus and multivalent filovirus vaccines and applied the same technology platform to rapidly develop a vaccine for the prevention of COVID-19, the infection caused by <abbr title=\"severe acute respiratory syndrome-coronavirus 2\">SARS-CoV-2<\/abbr>.<\/p>\n<ul>\n<li>Related <em><abbr>糖心视频<\/abbr> News<\/em> story: <a href=\"https:\/\/www.hawaii.edu\/news\/2019\/02\/22\/uh-ebola-vaccine-withstands-high-heat\/\">Ebola virus developed by <abbr>糖心视频<\/abbr> can withstand high heat<\/a>, February 22, 2019<\/li>\n<\/ul>\n<p>&ldquo;Our work to date has demonstrated not only the feasibility of rapid and efficient manufacturing of the required vaccine antigens, but also the potential for a broadly applicable and easily distributed vaccine,&rdquo; said Lehrer. &ldquo;We are delighted with our earlier successes on development of filovirus and flavivirus vaccines with this platform.&rdquo;<\/p>\n<p>Their vaccine candidate successfully demonstrates the ability to rapidly stimulate a balanced antibody response, which includes potent <abbr>SARS-CoV-2<\/abbr> neutralization and cell-mediated immunity, a measure necessary to clear a viral infection. In addition, the results generated by Lehrer and his team in a well-defined mouse model using a prototype virus antigen display a rapid onset of immunity with antibody responses detected as early as seven days after the first vaccination.<\/p>\n<ul>\n<li><a href=\"https:\/\/www.uhfoundation.org\/give\/giving-opportunity\/covid-19\">Support the <abbr>糖心视频<\/abbr> Student Relief fund and COVID-19 research<\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/biorxiv.org\/cgi\/content\/short\/2020.07.24.220715v1\">A manuscript<\/a> presenting the data has been submitted for peer review to <em>npj Vaccines<\/em> and is available as a preprint on bioRxiv.<\/p>\n<p><a href=\"https:\/\/jabsom.hawaii.edu\/researchforcovid19vaccineinearlytrials\/\">Read more on the JABSOM website<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Axel Lehrer with the John A. Burns School of Medicine is working with Soligenix, Inc. <\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[1411,1417,31,1363,158,429,9],"class_list":["post-123581","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-covid-19","tag-covid-19-research","tag-john-a-burns-school-of-medicine","tag-manoa-research","tag-publication","tag-tropical-medicine-and-medical-microbiology","tag-uh-manoa","entry","has-media"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.2 - aioseo.com -->\n\t<meta name=\"description\" content=\"Axel Lehrer, with the University of Hawaii at Manoa John A. 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